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Abstract #45683 Published in IGR 13-2
Evaluation impact of long-term usage of inhaled Fluticasone propionate on ocular functions in children with asthma
Emin O; Fatih M; Mustafa O; Nedim S; Osman CSteroids 2011; 76: 548-552
Objective: Although systemic, topical, and periocular corticosteroid administration have long been associated with ocular side effects, there has been little evidence to suggest that long-term inhaled corticosteroids can cause ocular side effects. The aim of this study was to evaluate the effects of long term treatment inhaled fluticasone propionate spray usage the recommended dose on some ocular functions in pediatric patients with asthma. Methods: The study group consisted of 266 prepubertal children with asthma who had used inhaled fluticasone propionate spray at 3-6 years intermittently. One hundred and sixty children who were newly diagnosed with asthma without any treatment made up the control group. Schirmer test results, central corneal thickness, visual acuity, intraocular pressure, cataract formation, keratometry and tear break-up time compared between study and control groups. Results: The ages of the 266 study patients (150 male) were between 7 and 11 years. The average age ((plus or minus)SEM) was 8.2 (plus or minus) 1.7 years, and the mean ((plus or minus)SEM) a daily dose of 323 (mu)g (range 250-450 (mu)g) inhaled fluticasone propionate spray, with 865.2 (plus or minus) 215 g total steroid use during treatment. Eye functions including cataract formation, corneal ectasia, ocular hypertension or glaucoma, and dry eye were not observed in any of the patients in the study group and were not correlated with total steroid dosage (t = 0.150, p = 0.384). Conclusion: Our findings suggest that long-term intermittent treatment for 3-6 years with inhaled fluticasone propionate spray, as much as average 320 (mu)g daily, in children with asthma seems to be safe for some eye functions
O. Emin. Department of Pediatrics, Bezmialem Vakif University, Medical Faculty, Istanbul, Turkey. Email: minozkaya@yahoo.com
Classification:
9.4.1 Steroid-induced glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
