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Abstract #45850 Published in IGR 13-2
Development of a Miniaturized HIFU Device for Glaucoma Treatment With Conformal Coagulation of the Ciliary Bodies
Charrel T; Aptel F; Birer A; Chavrier F; Romano F; Chapelon J-Y; Denis P; Lafon CUltrasound in Medicine and Biology 2011; 37: 742-754
This study examined the feasibility of high-intensity focused ultrasound (HIFU) for glaucoma treatment with conformal coagulation of the ciliary bodies (CB). A miniaturized high frequency (21 MHz) device was developed, based on the geometry of the eye and adapted to the anatomy of the rabbit eyeball. Six line-focus lesions were distributed along a circle and produced by six cylindrical transducers. To be conformal, the numerical model predicted an intensity of 6.9 W/cm(2), with exposure duration of 3 s ON (powered per sector). In vivo experiments were conducted on two rabbits. A significant intraocular pressure reduction was noted (-45% and -31%). Histology demonstrated conformal and homogeneous coagulation of the CB without side effects.
T. Charrel. U556 Inserm, 151 cours Albert Thomas, 69424 Lyon, Cedex 03, France. Email: thomas.charrel@inserm.fr
Classification:
12.10 Cyclodestruction (Part of: 12 Surgical treatment)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
