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Abstract #45937 Published in IGR 13-2
Enhancement of anti-glaucoma potential by novel ocular drug delivery system
Gupta S; Gilhotra RMInternational Journal of Pharmacy and Pharmaceutical Sciences 2011; 3: 55-58
Brimonidine is an anti glaucoma agent useful in treatment of IOP. An attempt has been made to formulate ophthalmic insert of brimonidine tartrate using HPMC, PVA, Chitosan and Sodium alginate by solvent casting method. The prepared ophthalmic insert were then evaluated for uniformity of thickness, weight, drug content, % moisture absorption, % moisture loss, folding endurance and surface pH.In vitro drug release of formulated batches of ophthalmic insert was performed by studying the diffusion through artificial cellophane membrane. On the basis of all physicochemical parameters and in vitro drug release studies, the formulation (F-1) with Chitosan (3%) was found to be promising and it was selected as an optimized formulation. The result of in vitrodiffusion study of F-1 exhibited zero order kinetic with higuchi diffusion mechanism drug release. The pharmacodynamics evaluation of F-1 in rabbit eye model indicated higher and longer IOP lowering potential of ocular insert as compared to eye drops. Chitosan based brimonidine ocular insert could be a potential vehicle to enhance ocular bioavailability and patient compliance.
S. Gupta. Pharmaceutics Division, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, 302025, India.
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
