advertisement
Abstract #45938 Published in IGR 13-2
Effect of a single drop of Latanoprost ophthalmic gel on intra ocular pressure in the treatment of glaucoma
Kulkarni SV; Sandeep HN; Shankar MS; Ranjit Kumar P; Someshwara Rao B; Ramesh B; Ashok Kumar PAInternational Journal of Pharmaceutical Sciences 2010; 2: 429-435
Glaucoma a disease characterized by optic nerve damage and visual field defect is often associated with an increase in the intraocular pressure (IOP). If left untreated, the disease can ultimately lead to blindness. Latanoprost (13, 14-dihydro-17-phenyl-18,19,20-trinorprostaglandin F2(alpha)-1-isopropyl ester) is a potent prostaglandin analogues developed for treatment of glaucoma. In the present study Latanoprost ophthalmic gel were developed with the aim of promoting the prolong release of drug using Carbopol, HPMC, and HPC polymers. The Latanoprost ophthalmic gels were sterilized and assessed for various parameters like clarity, physical appearance, pH, viscosity and in vitro drug release studies. We compared IOP lowering effect with gels to those of Latanoprost eye drops in healthy rabbits, after induction of IOP in the rabbits by suitable methods. The prepared gels showed similar decrease in IOP as that of standard Latanoprost eye drops and was found that ophthalmic gels exhibited prolonged anti glaucoma activity over a period of 6 hrs, where as eye drop showed shorter duration of action. IOP measurements were done using Reister Tonometer. The results indicate that controlled drug delivery is a viable alternative in improving the therapeutic index by decreasing systemic absorption.
S.V. Kulkarni. Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, India. Email: drsvk.sscp@gmail.com
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.4 Prostaglandins (Part of: 11 Medical treatment)
