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Background: Elevated intraocular pressure (IOP) is a risk factor for the development and progression of glaucoma. Therefore, measuring IOP is essential to the diagnosis of glaucoma and monitoring of treatment. Goldmann applanation tonometry is known as the gold standard for measuring IOP in clinic. Objective: This clinical trial tried to assess the agreement of IOP measured by iCare rebound tonometer (RBT) and Goldmann applanation tonometer (GAT) and compare their accuracy and safety. Methods: IOP was measured with RBT and GAT respectively in 104 normal eyes of 52 patients with the mean age 48 years old (range 19-76). The patients were divide into (less-than or equal to) 10 mmHg (Group I), 11-20 mmHg (Group II), 21-30 mmHg (Group III), 31-40 mmHg (Group IV), (greater-than or equal to)41 mmHg (Group V) according to the IOP readings of GAT. The statistical difference of IOP readings obtained by RBT and GAT were compared using the paired t test, and the correlation between RBT readings and GAT readings was assessed using linear regression correlation analysis. The oral informed consent was obtained from each patient prior to this trial. Results: IOP readings obtained by RBT was 17.20 (plus or minus) 9.13 mmHg, and that by GAT was 17.13 (plus or minus) 8.94 mmHg without significant difference between them (t = 0.260, P = 0.795). 60.58% patients showed the IOP difference within 1 mmHg between the two methods. The absolute IOP difference was gradually large as the increase of IOP readings with the largest value in (greater-than or equal to)41 mmHg group. The largest difference value between the two methods was less 4 mmHg. The IOP readings from RBT varied as CAT with a good correlation (r = 0.917, P < 0.01), but the readings measured by RBT showed a slightly overestimated tendency in comparison with those of GAT. The sensitivity and specificity of RBT was 95.5% and 98.8% respectively when GAT IOP was >21 mmHg. Foreign body sensation and ocular dryness were complained in 25% patients (26 of 104) after measured with RBT. Conclusion: RBT is well tolerated and safe. RBT appears to correlate well with GAT in IOP measurement, and it could be useful in clinical application.
Y. He. Department of Ophthalmology, Kunming Medical College, Kunming 650032, China.
6.1.1 Devices, techniques (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)