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Abstract #46068 Published in IGR 13-2
Investigation of the association between SLC1A3 gene polymorphisms and normal tension glaucoma
Yasumura R; Meguro A; Ota M; Nomura E; Uemoto R; Kashiwagi K; Mabuchi F; Iijima H; Kawase K; Yamamoto TMolecular Vision 2011; 17: 792-796
Purpose: To investigate whether the solute carrier family 1, member 3 (SLC1A3) gene, which encodes the glutamate aspartate transporter, is associated with normal tension glaucoma (NTG) in Japanese patients. Methods: Two hundred and ninety-five Japanese patients with NTG and 518 Japanese healthy controls were recruited. Patients exhibiting comparatively early NTG onset were selected because early onset suggests that genetic factors may show stronger involvement. We genotyped 5 single-nucleotide polymorphisms (SNPs) in SLC1A3 and assessed the allelic and genotypic diversity among cases and controls. Results: There were no statistically significant differences in the frequency of SLC1A3 alleles and genotypes between cases and controls. Conclusions: Our study showed no association between SLC1A3 and NTG, suggesting that the SLC1A3 gene may not be an associated factor in NTG pathogenesis.
A. Meguro. Department of Ophthalmology, Visual Science Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. Email: akmeguro@yokohama-cu.ac.jp
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
