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Abstract #46085 Published in IGR 13-2
Longitudinal reproducibility of optical coherence tomography measurements in children
Prakalapakorn SG; Freedman SF; Holgado S; Chen BB; El-Dairi MAJournal of AAPOS 2011; 15: 27
Introduction: In healthy eyes of children, optical coherence tomography (OCT) measurements of macular and retinal nerve fiber layer (RNFL) thickness are reproducible within the same day and average RNFL has been correlated with axial length (AL). We evaluated longitudinal reproducibility of OCT measurements in children as AL changed. Methods: As part of an ongoing prospective study comparing the reproducibility of OCT measurements in children, Stratus OCT(Carl Zeiss) was used to obtain fast macular and fast RNFL thickness protocols on healthy(n = 8) and glaucoma/glaucoma suspect (G/ GS) (n = 19, n = 7, respectively) eyes of children on three visits over an average of 3 years. Results: On initial visit, normal versus G/GS eyes had a mean total macular volume (MV) of 7.0 (plus or minus) 0.3 mm(3) versus 6.8 (plus or minus) 0.6 mm(3), respectively, and an average RNFL thickness of 107.0 (plus or minus) 8.6 (mu)m versus 98.8 (plus or minus) 28.5 (mu)m, respectively. Likewise, mean coefficient of variation for total MV was 1.4% vs 2.3%, respectively and for average RNFL was 2.7% vs 5.6%, respectively. Among normal versus G/GS eyes, the intraclass correlation coefficients(ICCs) between visits for total MV were 0.98 vs 0.95 (first/second visits), 0.91 vs 0.89 (second/third visits) and 0.84 vs 0.80 (first/third visits), respectively. Similarly, ICCs for RNFL thickness were 0.85 vs 0.96 (first/second visits), 0.85 vs 0.97 (second/third visits) and 0.88 vs 0.93 (first/third visits), respectively. Among the normal eyes, average AL (23.48 (plus or minus) 0.58 mm at initial visit) increased 0.14 (plus or minus) 0.13 mm/year. Conclusions: Among children, global OCT measurements were reproducible over years. Among normal eyes, the reproducibility of OCT measurements was unaffected by AL change. Both normal and G/GS eyes showed high reproducibility for OCT measurements of total MV and average RNFL thickness. OCT shows promise as an objective tool for longitudinal assessment of total MV and average RNFL thickness in children.
S.G. Prakalapakorn.
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)