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Abstract #46086 Published in IGR 13-2
Long-term outcome of primary congenital glaucoma
de Silva DJ; Khaw PT; Brookes JLJournal of AAPOS 2011; 15: 148-152
See also comment(s) by James Brandt •
Purpose: To evaluate the long-term outcome of primary congenital glaucoma in patients followed for more than 20 years. Methods: All patients with a diagnosis of congenital glaucoma who were examined in the pediatric glaucoma clinic at Moorfields Eye Hospital from 2005 to 2006 were included. The follow-up period was a minimum of 20 years; patients with pediatric glaucoma secondary to other etiologies were excluded. Data collected included visual acuity, optic disk cupping, intraocular pressure (IOP), corneal diameter, pachymetry, visual fields, refraction, strabismus, glaucoma management, and ocular comorbidity. Progressive congenital glaucoma, defined as an increase of the cup/disk ratio of >0.2 secondary to elevated IOP, was evaluated with the use of Kaplan-Meier survival curves. Patients were divided into 1of 3 groups: (1) stable glaucoma with no visual impairment; (2) glaucoma progression with sight-threatening consequences; and (3) poor visual acuity as a result of ocular comorbidity. Results: A total of 30 eyes of 16 patients were identified. Mean follow-up was 34 (plus or minus) 10 years (range, 22-59 years). At the final clinical assessment, mean IOP was 13.6 (plus or minus) 4.3 mm Hg and mean cup/disk ratio was 0.7 (plus or minus) 0.3 (p < 0.05). Survival analysis demonstrated lack of progression in 90.3% at 1 year, 83.1% at 5 years, 70.8% at 10 years, 58.3% at 34 years, and 48.6% at 40 years. Conclusions: Apparently stable congenital glaucoma may progress with sight-threatening complications after many years of IOP stability. Monitoring of these patients is indicated throughout life.
D. J. De Silva. Moorfields Eye Hospital, London, United Kingdom. Email: julian.desilva@moorfields.nhs.uk
Classification:
9.1.1 Congenital glaucoma, Buphthalmos (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
