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Abstract #46103 Published in IGR 13-2
Visual field protective effect of erigeron breviscapus (vant.) hand. mazz. extract on glaucoma with controlled intraocular pressure: A randomized, double-blind, clinical trial
Zhong Y; Xiang M; Ye W; Cheng Y; Jiang YDrugs in R&D 2010; 10: 75-82
Objective: To evaluate the visual field protective effect of Erigeron breviscapus (vant.) Hand. Mazz. (EBHM) extract on glaucoma with controlled intraocular pressure (IOP). Methods: Forty patients (40 eyes) with primary open-angle glaucoma, visual field defects and a postsurgical IOP of <18mmHg were enrolled. The EBHM and placebo tablets were given orally according to the randomized and double-blind principle. Two tablets (of either EBHM or placebo) were taken three times a day for a period of 6 months. Patients were examined every 2 months after treatment commenced. At the end of the study, the results were given to the drug manufacturer. Results: All patients completed the prospective, randomized, double-blind, clinical trial. No obvious adverse effects were found in patients during the treatment period. In the placebo group, no significant difference was found in mean defect (MD) or mean sensitivity (MS) between the values at pretreatment and after 2, 4, and 6 months of treatment. After 6 months of EBHM treatment, the MD was significantly decreased and the MS was significantly increased compared with pre-treatment (p<0.05). In the patients with moderate and late glaucoma, the MD was significantly decreased and the MS was significantly increased after 2, 4, and 6 months of EBHM treatment compared with pre-treatment. Conclusion: EBHM extract may have a partial protective effect on the visual field of glaucoma patients with controlled IOP. Further studies are needed to determine the safety and effectiveness of long-term EBHM treatment.
Y. Zhong. Department of Ophthalmology, Shanghai Jiaotong University, Ruijin Hospital, 197 Ruijin No. 2 Road, 200025 Shanghai, China. Email: yszhong68@yahoo.com.cn
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
