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Abstract #46111 Published in IGR 13-2
Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: A randomized clinical trial
Mostafaei AClinical Ophthalmology 2011; 5: 491-494
Objective: The aim of this study was to compare the efficacy of augmenting trabeculectomy with subconjunctival mitomycin C (TMMC) versus 5-fluorouracil (T5-FU) in lowering intraocular pressure (IOP). Methods: Forty eyes from 40 patients referred to the Nikoukari Ophthalmology University Hospital, Tabriz University of Medical Sciences, Tabriz, Iran, were enrolled in a randomized clinical trial. Patients with high-risk open angle glaucoma were allocated to receive either subconjunctival TMMC or T5-FU. Results: Mean overall preoperative IOP was 30.8 mmHg. Mean preoperative IOPs in the TMMC and T5-FU groups were 31.2 (plus or minus) 9.8 and 30.6 (plus or minus) 9.9 mmHg, respectively. Postoperatively, mean IOPs were 11.4.3 (plus or minus) 4.9 and 13.6 (plus or minus) 3.9 mmHg, respectively for TMMC and T5-FU groups after 6 months. In spite of some existing descriptive differences in IOP between the groups, statistical tests showed no difference in mean and median IOP. Three cases of hypotonia (IOP, 6 mmHg) and 1 case of epithelial keratitis were detected. Conclusion: TMMC and T5-FU appeared to have similar efficacy in lowering IOP.
A. Mostafaei. Nikoukari Eye Hospital, Abbasi Street, Tabriz, Iran. Email: ali.mostafaei.tabriz@gmail.com
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
