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Abstract #46277 Published in IGR 13-2
Variability in short-wavelength automated perimetry among peri- or postmenopausal women: A dependence on phyto-oestrogen consumption?
Eisner A; Demirel SActa Ophthalmologica 2011; 89: 217-224
Purpose: To determine whether the hill of vision for Short-Wavelength Automated Perimetry (SWAP) is shallower for women who consume phyto-oestrogen-rich foods than for women who do not. Methods: Visual field data were compared for two groups of healthy amenorrhoeic women 48-69 years-old with normal vision and not using hormone replacement: (1) 24 subjects who reported consuming soy and/or flax products and (2) 20 subjects who reported not consuming these products. Two types of 24-2 visual fields were measured: (1) Full Threshold SWAP and (2) a white-on-white (W/W) field obtained using a Swedish Interactive Threshold Algorithm (SITA Standard). Results: The reduction of SWAP sensitivity from the centre of the field (4 loci, mean eccentricity = 4.2(degrees)) to the periphery (20 loci, mean eccentricity = 21.9(degrees)) was less for soy/flax consumers than for nonconsumers, both with age-referencing (mean difference = 1.7 dB, p = 0.018) and without (p = 0.012). Corresponding distinctions existed for the SWAP - W/W difference, and there was minimal effect for W/W fields alone. The peripheral age-referenced SWAP sensitivities averaged 2.5 dB higher for consumers than nonconsumers (p = 0.022). Conclusion: The between-group distinctions are consistent with the possibility (derived from the women's health literature) that phyto-oestrogens may counteract a decline of short-wavelength-sensitive cone-mediated response among postmenopausal women. These results suggest another potential application for SWAP outside its original intended purpose as a glaucoma test. Future studies should assess whether phyto-oestrogen consumption is most beneficial for women who are sufficiently young and/or not too far beyond menopause.
A. Eisner. Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd., Portland, OR 97239, United States. Email: eisnera@ohsu.edu
Classification:
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
