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Abstract #46305 Published in IGR 13-2
Quantification of retinal nerve fiber layer thickness in normal eyes, eyes with ocular hypertension, and glaucomatous eyes with SD-OCT
Mansoori T; Viswanath K; Balakrishna NOphthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 2010; 41: 50-57
To quantitatively evaluate and compare retinal nerve fiber layer (RNFL) thickness between normal eyes, eyes with ocular hypertension (OHT), and glaucomatous eyes in an Indian population using spectral domain optical coherence tomography (SD-OCT). Average and quadrant RNFL values were compared among three groups (66 normal eyes, 55 OHT eyes, and 51 glaucomatous eyes) and the discriminating power of each parameter was evaluated by calculating areas under receiver operator curves (AROCs). The mean RNFL thickness was 93.45 (plus or minus) 16.9 (mu)m in glaucomatous eyes, significantly less than in normal (112.48 (plus or minus) 6.8 (mu)m) and OHT (110.09 (plus or minus) 10.9 (mu)m) eyes. OHT eyes had significantly thinner RNFL thickness in the temporal quadrant (P = .006) than normal eyes. RNFL thickness in glaucomatous eyes differed significantly from normal eyes in most parameters except nasal quadrant (P = .1) and from OHT eyes in most parameters except temporal (P = .4) and nasal quadrants (P = .3). The parameter with the largest AROC to discriminate between OHT and normal eyes was temporal quadrant (0.65). Inferior quadrant RNFL thickness had the largest AROC (0.93) to distinguish between OHT and glaucomatous eyes and normal and glaucomatous eyes. SD-OCT identified differences in most parameters between eyes with glaucoma and normal eyes and also between eyes with glaucoma and OHT. Overlap of RNFL thickness between normal and OHT eyes limits the ability of this instrument to differentiate between normal and OHT subjects.
T. Mansoori. Department of Glaucoma, Pushpagiri Eye Institute, 241 Uma Plaza, Road No. 9, West Marredpally, Secunderabad, Andhra Pradesh, India. Email: tarannummansoori@yahoo.com
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
