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1 General aspects (0)   1.1 Epidemiology (14)   1.2 Population genetics (0)   1.3 Pathogenesis (2)   1.4 Quality of life (11)   1.5 Glaucomas as cause of blindness (10)   1.6 Prevention and screening (13) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (12)   2.2 Cornea (30)   2.3 Sclera (2)   2.4 Anterior chamber angle (8)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (17)     2.5.2 Schlemms canal (1)     2.5.3 Scleral outlet channels (2)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (5)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (3)   2.7 Episcleral veins and venous pressure (4)   2.8 Iris (5)   2.9 Ciliary body (5)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (7)   2.13 Retina and retinal nerve fibre layer (30)   2.14 Optic disc (28)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (6)   2.17 Stem cells (1)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (3)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (6)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (3)     3.4.2 Gene studies (39)   3.5 Molecular biology incl. 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pharmacoeconomics (4) 15 Miscellaneous (37)

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Abstract #46317 Published in IGR 13-2

Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors

Chen YT; Vojkovsky T; Fang X; Pocas JR; Grant W; Handy AMW; Schroter T; LoGrasso P; Bannister TD; Feng Y
MedChemComm 2011; 2: 73-75

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Rho kinase (ROCK) is currently investigated as a target for various diseases such as glaucoma and spinal cord injury. Herein, we report the asymmetric synthesis of chroman 1, a highly potent ROCK inhibitor, and its analogs. The inhibitory properties of these compounds for ROCK-II and a selected set of highly homologous kinases are also discussed.

T. D. Bannister. Translational Research Institute, Scripps Florida, 130 Scripps Way #2A1, Jupiter FL 33458, United States. Email: tbannist@scripps.edu

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Classification:

11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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