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Abstract #46407 Published in IGR 13-3
The immune response in glaucoma: A perspective on the roles of oxidative stress
Tezel GExperimental Eye Research 2011; 93: 178-186
Neurodegenerative insults and glial activation during glaucomatous neurodegeneration initiate an immune response to restore tissue homeostasis and facilitate tissue cleaning and healing. However, increasing risk factors over a chronic and cumulative period may lead to a failure in the regulation of innate and adaptive immune response pathways and represent a route for conversion of the beneficial immunity into a neuroinflammatory degenerative process contributing to disease progression. Oxidative stress developing through the pathogenic cellular processes of glaucoma, along with the aging-related component of oxidative stress, likely plays a critical role in shifting the physiological equilibrium. This review aims to provide a perspective on the complex interplay of cellular events during glaucomatous neurodegeneration by proposing a unifying scheme that integrates oxidative stress-related risk factors with the altered regulation of immune response in glaucoma.
Department of Ophthalmology & Visual Sciences, University of Louisville, Louisville, KY, USA.
Classification:
3.10 Immunobiology (Part of: 3 Laboratory methods)
1.3 Pathogenesis (Part of: 1 General aspects)
