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Abstract #46427 Published in IGR 13-3
Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension
Portmann N; Gugleta K; Kochkorov A; Polunina A; Flammer J; Orgul SInvestigative Ophthalmology and Visual Science 2011;
See also comment(s) by Alon Harris •
PURPOSE: To analyze submacular choroidal blood flow response to isometric exercise in untreated patients with glaucoma and ocular hypertension. METHODS: We continuously measured choroidal blood flow (ChBF) by means of confocal laser Doppler flowmetry during 5 minutes of baseline, during 90 seconds of isometric exercise with a Martin's vigorimeter and during 15 minutes of recovery. Values from one randomly chosen eye of 45 healthy subjects, the eye with more advanced damage in 45 open angle glaucoma (POAG) patients and the eye with higher native intraocular pressure in 45 ocular hypertensives (OHT) were acquired, and parameters of ChBF as well as blood pressure response were analyzed. RESULTS: Healthy eyes demonstrated higher ChBF at baseline than both other groups (5126 ± 1487, 4186 ± 1011, 4437 ± 1372 arbitrary units, ANOVA p=0.003). Both mean and diastolic arterial blood pressures at baseline were lower in POAG than in OHT patients and healthy controls (p<0.03), however, the response of mean blood pressure to isometric exercise was comparable across groups (p=0.79). The ChBF response to exercise was stronger in the POAG group (ANOVA p=0.02), it was double higher than in controls (+8.1 ± 8.0% vs. +3.7 ± 6.7%, p=0.007) and borderline higher versus OHT patients (latter +5.0 ± 8.0%; p=0.051). CONCLUSIONS: Baseline ChBF was lower in both POAG and OHT patients, compared to controls. Stronger increase of ChBF in POAG patients in the face of exercise-induced blood pressure rise indicates less active regulatory capacity in glaucoma patients.
Ophthalmology Department, University Hospital Basel, Basel, Switzerland.
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
