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Abstract #46476 Published in IGR 13-3
Structure-function relationship in glaucoma using spectral-domain optical coherence tomography
Rao HL; Zangwill LM; Weinreb RN; Leite MT; Sample PA; Medeiros FAArchives of Ophthalmology 2011; 129: 864-871
See also comment(s) by Gustavo de Moraes •
Objectives: To determine the structure-function relationship in glaucoma using spectral-domain optical coherence tomography (SDOCT)-derived structural measurements and to evaluate this relationship using a linear model. Methods: In a cross-sectional study, structure-function relationships were determined for all the participants in the DIGS (Diagnostic Innovations in Glaucoma Study) and the ADAGES (African Descent and Glaucoma Evaluation Study) who had undergone standard automated perimetry (SAP) and SDOCT within 6 months of each other. Strength of relationship was reported as coefficient of determination (R2). The relationship was also evaluated using a previously described linear model. Results: The results of 579 SAP and SDOCT examinations from 80 eyes of 47 control subjects, 199 eyes of 130 patients with suspected glaucoma, and 213 eyes of 146 patients with glaucoma were analyzed. The R2 for the association between SAP total deviation and SDOCT variables ranged from 0.01 (P=.02) for the nasal rim area to 0.30 (P<.001) for inferior inner retinal thickness at the macula. The linear model fitted the data well. Conclusions: The strongest structure-function associations using SDOCT were found for retinal nerve fiber layer measurements at arcuate areas and inner retinal thickness at the macula measurements. The linear model is useful in studying the structure-function relationship in glaucoma.
F. A. Medeiros. Hamilton Glaucoma Center, Department of Ophthalmology, University of California at San Diego, San Diego, CA, United States.
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
