advertisement
Abstract #46477 Published in IGR 13-3
Racial differences in ocular oxidative metabolism: Implications for ocular disease
Siegfried CJ; Shui Y-B; Holekamp NM; Bai F; Beebe DCArchives of Ophthalmology 2011; 129: 849-854
See also comment(s) by Jonathan Crowston •
Objective: To compare the PO(2) distribution in different regions in the eyes of patients undergoing intraocular surgery. Methods: Before initiation of intraocular cataract and/or glaucoma surgery, an optical oxygen sensor was introduced into the anterior chamber via a peripheral corneal paracentesis. The tip of the flexible fiberoptic probe was positioned by the surgeon for 3 measurements in all patients: (1) near the central corneal endothelium, (2) in the mid-anterior chamber, and (3) in the anterior chamber angle. In patients scheduled to undergo cataract extraction, PO(2) was also measured (4) at the anterior lens surface and (5) in the posterior chamber just behind the iris. Oxygen measurements at the 5 locations were compared using a 2-tailed unpaired t test and multivariate regression. Results: The PO (2) value was significantly higher in African American patients at all 5 locations compared with Caucasian patients. Adjusting for age increased the significance of this association. Adjusting for race revealed that age was associated with increased PO(2) beneath the central cornea. Conclusions: Racial differences in oxygen levels in the humaneye reflect an important difference in oxidative metabolism in the cornea and lens and may reflect differences in systemic physiologic function. Increased oxygen or oxygen metabolites may increase oxidative stress, cell damage, intraocular pressure, and the risk of developing glaucoma. Oxygen use by the cornea decreases with age.
C. J. Siegfried. Campus Box 8096, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, United States.
Classification:
3.9 Pathophysiology (Part of: 3 Laboratory methods)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
