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Abstract #46506 Published in IGR 13-3
The effects of midazolam on intraocular pressure in children during examination under sedation
Oberacher-Velten I; Prasser C; Rochon J; Ittner K-P; Helbig H; Lorenz BBritish Journal of Ophthalmology 2011; 95: 1102-1105
Background: To obtain reliable and accurate measurements of the intraocular pressure (IOP) in children often requires sedation or anaesthesia. Therefore, we investigated the effects of oral midazolam on IOP in children. Methods: In a prospective study, IOP was measured in 72 eyes of 36 cooperative children without glaucoma requiring general anaesthesia (mean age 3.5(plus or minus)1.3 years, body weight (less-than or equal to)20 kg) by using a Perkins hand-held tonometer. Measurements of IOP were performed before, and 15 and 30 min after sedation with orally administered midazolam (1 mg/kg) given as preoperative medication, and 5 and 15 min after induction of general anaesthesia. The individual IOP courses were analysed. Results: In all of the cooperative children, IOP measurement was possible after sedation with midazolam. Mean IOP was 11.2(plus or minus)0.3 mmHg before sedation, 10.9(plus or minus)0.2 mmHg at 15 min, and 10.7(plus or minus)0.3 mmHg 30 min after administration of midazolam. This small decrease was not statistically significant, whilst the IOP decline at 5 and 15 min after induction of general anaesthesia was statistically significant (p<0.0001). Conclusion: Sedation with midazolam can be assumed to be an applicable, well-tolerated, safe method for IOP measurements in children.
I. Oberacher-Velten. University Eye Hospital, Klinikum of the University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany.
Classification:
12.17 Anesthesia (Part of: 12 Surgical treatment)
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
