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Abstract #46511 Published in IGR 13-3
Comparing rates of retinal nerve fibre layer loss with GDxECC using different methods of visual-field progression
Grewal DS; Sehi M; Greenfield DS; Quinn CD; Kishor K; Schuman JS; Noecker RJ; Ishikawa H; Wollstein G; Billonick RABritish Journal of Ophthalmology 2011; 95: 1122-1127
Background: This prospective analysis was designed to examine the rate of RNFL loss using scanning laser polarimetry (GDx enhanced corneal compensation (GDxECC)) in progressing versus non-progressing eyes using various methods to define functional progression. Methods: Glaucoma suspect and glaucomatous eyes with (greater-than or equal to)3 years of follow-up participating in the Advanced Imaging for Glaucoma Study were enrolled. All eyes underwent standard automated perimetry (SAP) and GDxECC imaging every 6 months. The annual rate of RNFL loss with GDxECC was calculated using linear regression analysis. Functional progression was determined using the Early Manifest Glaucoma Trial (EMGT) criterion, SAP Visual Field Index (VFI) and Progressor software. Results: Fifty-three eyes (30 glaucoma suspect, 23 glaucoma) of 53 patients (mean age 64.5(plus or minus)10.7 years, range 42-79) were enrolled. Eighteen eyes (40%) demonstrated SAP progression during the follow-up period using the Progressor criterion, 10 eyes (18.9%) using the VFI criterion, and 3 eyes (5.7%) using the EMGT criterion. The annual rate (mm/year) of mean RNFL loss was significantly greater (p<0.05) in progressing versus non-progressing eyes using Progressor (-1.24(plus or minus)0.99 vs -0.18(plus or minus)0.49), EMGT (-1.95(plus or minus)0.99 vs -0.46(plus or minus)0.78) and VFI (-1.11(plus or minus)0.64 vs -0.41(plus or minus)0.85) criteria. Conclusion: Despite differences in the criteria used to judge functional progression, progressing eyes have a significantly greater rate of RNFL loss measured using GDxECC as compared with non-progressing eyes.
M. Sehi. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL, United States.
Classification:
6.9.1.2 Confocal Scanning Laser Polarimetry (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.20 Progression (Part of: 6 Clinical examination methods)
