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Abstract #46521 Published in IGR 13-3
Beta-zone parapapillary atrophy and multifocal visual evoked potentials in eyes with glaucomatous optic neuropathy
De Moraes CG; Ketner S; Teng CC; Ehrlich JR; Raza AS; Liebmann JM; Ritch R; Hood DCDocumenta Ophthalmologica 2011; 123: 43-50
We investigated changes in multifocal visual evoked potential (mfVEP) responses due to beta-zone parapapillary atrophy ((beta)PPA). Patients with glaucomatous optic neuropathy (GON) with or without standard achromatic perimetry (SAP) abnormalities were referred for mfVEP testing during a 2-year period. Eyes with good quality optic disc stereophotographs and reliable SAP results were included. The mfVEP monocular mean latency delays (ms) and amplitudes (SNR) were analyzed. Age, SAP mean deviation (MD), pattern standard deviation (PSD), and spherical equivalent (SE) were analyzed in the multivariate model. Generalized estimated equations were used for comparisons between groups after adjusting for inter-eye associations. Of 394 eyes of 200 patients, 223 (57%) had (beta)PPA. The (beta)PPA eyes were older (59.6 (plus or minus) 13.7 vs. 56.5 (plus or minus) 13.7 year, P = 0.02), more myopic (-4.0 (plus or minus) 3.5 vs. -1.3 (plus or minus) 3.5 D, P < 0.01), and had poorer SAP scores (MD: -4.9 (plus or minus) 5.2 vs. -2.6 (plus or minus) 5.2 dB, P < 0.01; PSD: 4.3 (plus or minus) 2.9 vs. 2.5 (plus or minus) 3.0 dB, P < 0.01). By univariate analysis, mean latencies were longer in (beta)PPA eyes (6.1 (plus or minus) 5.3 vs. 4.0 (plus or minus) 5.5 ms, P < 0.01). After adjusting for differences in SE, age, and SAP MD, there was no significant difference between the two groups (P = 0.09). (beta)PPA eyes had lower amplitude log SNR (0.49 (plus or minus) 0.16 vs. 0.56 (plus or minus) 0.15, P < 0.01), which lost significance (P = 0.51) after adjusting for MD and PSD. Although eyes with (beta)PPA had significantly lower amplitudes and prolonged latencies than eyes without (beta)PPA, these differences were attributable to differences in SAP severity, age, and refractive error. Thus, (beta)PPA does not appear to be an independent factor affecting mfVEP responses in eyes with GON.
C.G. De Moraes. Einhorn Clinical Research Center, New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, United States.
Classification:
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
