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Abstract #46532 Published in IGR 13-3
Molecular genetics in glaucoma
Liu Y; Allingham RRExperimental Eye Research 2011;
Glaucoma is a family of diseases whose pathology is defined by the progressive loss of retinal ganglion cells. Clinically, glaucoma presents as a distinctive optic neuropathy with associated visual field loss. Primary open-angle glaucoma (POAG), chronic angle-closure glaucoma (ACG), and exfoliation glaucoma (XFG) are the most prevalent forms of glaucoma globally and are the most common causes of glaucoma-related blindness worldwide. A host of genetic and environmental factors contribute to glaucoma phenotypes. This review examines the current status of genetic investigations of POAG, ACG, XFG, including the less common forms of glaucoma primary congenital glaucoma (PCG), the developmental glaucomas, and pigment dispersion glaucoma.
R.R. Allingham. Duke University Eye Center, Duke University Medical Center, Durham, NC, USA, .
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
3.4.1 Linkage studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
