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Abstract #46545 Published in IGR 13-3
Improved prediction of fellow-eye response in one-eye trials using multiple intraocular pressure measurements
Wakabayashi Y; Higashide T; Sugiyama KJapanese Journal of Ophthalmology 2011; 55: 480-485
See also comment(s) by Tony Realini •
Purpose: To examine the effects of multiple intraocular pressure (IOP) measurements on the correlation of response to glaucoma medication between fellow eyes. Methods: Latanoprost was applied to the first eye and then to both eyes of 16 patients with either primary open-angle glaucoma or ocular hypertension. IOP measurements were performed twice on different days for each of three periods: at baseline, during treatment of the first eye only and for both eyes. IOP decreases in the first and second eyes were evaluated with {increment}IOP 1 (=IOP at baseline - IOP after treatment) and {increment}IOP 2 (={increment}IOP 1 - IOP fluctuation of the contralateral eye). The correlation of IOP decreases between the fellow eyes was analyzed by linear regression analysis using the Pearson correlation coefficient, r. Results: No significant correlations of {increment}IOP1 between fellow eyes were found regardless of the number of IOP measurements. {increment}IOP2 was significantly correlated between fellow eyes using two post-treatment IOP measurements, but not with a single post-treatment IOP. Conclusions: Using multiple post-treatment IOP measurements may improve the prediction of a fellow eye's response to glaucoma medication in one-eye trials.
T. Higashide. Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, 9208641, Ishikawa, Japan.
Classification:
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
