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The optineurin (OPTN) gene, known to be implicated in primary open-angle glaucoma (POAG), is the more recent genetic factor linked to ALS. We report the case of a 75 year-old man who developed ALS and whose medical history was dominated by a familial POAG. The absence of OPTN gene mutation in a patient who suffered from two conditions linked to mutations of this gene does not support involvement of OPTN in ALS.
P. Corcia. Centre SLA, CHRU de Tours, Tours, France, .
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)