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Abstract #46561 Published in IGR 13-3
A Detailed Meta-Analysis Shows No Association between TNF-(alpha) -308G/A Polymorphism and Different Forms of Glaucoma
Yu Q-Q; Yao YOphthalmic Research 2011; 47: 47-51
Objective: Glaucoma is the second leading cause of blindness worldwide. To date, several publications have evaluated the association between the tumor necrosis factor (alpha) (TNF-(alpha)) -308G/A polymorphism and glaucoma risk. However, the results remain inconclusive. The aim of our study was to clarify the effect of the TNF-(alpha) -308G/A polymorphism on glaucoma risk. Method: We conducted searches of the published literature in the PubMed database updated to May 2010. A meta-analysis was performed by critically reviewing 7 publications with a total of 1,199 glaucoma cases and 1,189 controls on the -308G/A polymorphism. Odds ratio (OR) and 95% confidence intervals (CIs) were used to assess the strength of this relationship. Results: Overall, no association between the TNF-(alpha) -308G/A polymorphism and primary open-angle glaucoma or pseudoexfoliation glaucoma risk was found in the A allele versus G allele genetic model (OR = 1.68, 95% CI = 0.78-3.59 or OR = 2.44, 95% CI = 0.40-15.04, respectively), the same as genetic models in AG versus GG and AA + AG versus GG. In the stratified analysis by ethnicity and source of control subgroups, a significant association was still not observed in all genetic models. Conclusion: Our meta-analysis provides strong evidence that the TNF-(alpha) -308G/A polymorphism is not associated with different forms of glaucoma risk.
Department of Ophthalmology, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China
Classification:
3.6 Cellular biology (Part of: 3 Laboratory methods)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
