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Miscellaneous (32)

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Abstract #46570 Published in IGR 13-3

An in vitro evaluation for corneal damages by anti-glaucoma combination eye drops using human corneal epithelial cell (HCE-T)

Nagai N; Murao T; Oe K; Ito Y; Okamoto N; Shimomura Y
Yakugaku Zasshi 2011; 131: 985-991

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The combination of anti-glaucoma eye drops is frequently used in clinical treatment, and it is known that the combination can cause corneal damage. Recently, an anti-glaucoma combination eye drops is developed, and the treatment by the combination eye drops is expected to enhance quality of life. However, effects of the combination eye drops on corneal epithelial cell damage have not been clarified. In this study, we investigated the corneal epithelial cell damage of commercially available anti-glaucoma combination eye drops, such as Xalacom(registered trademark) (latanoprost/timolol maleate combination eye drops), Duotrav(registered trademark) (travoprost/timolol maleate combination eye drops) and Cosopt(registered trademark) (dorzolamide hydrochloride/timolol maleate combination eye drops) using the human corneal epithelial cell (HCE-T). The cytotoxicity in Xalacom(registered trademark) was higher than that in Xalatan(registered trademark) (eye drops containing latanoprost) and Timoptol(registered trademark) (eye drops containing timolol maleate), and the benzalkonium chloride (BAC) and timolol maleate were related to cytotoxicity in Xalacom (registered trademark). The cytotoxicity in Duotrav(registered trademark) and Cosopt(registered trademark) was lower than that in Timoptol(registered trademark). The Duotrav(registered trademark) is preserved with a non-BAC system (POLYQUAD, polidronium chloride). Therefore, it was suggested that the POLYQUAD related to the low cytotoxicity in Duotrav(registered trademark). On the other hand, the D-mannitol reduced the cytotoxicity by BAC in this study. This result suggested that the cytotoxicity in Cosopt(registered trademark) was reduced by D-mannitol. The Duotrav(registered trademark) and Cosopt(registered trademark) may be less damaging to the ocular surface of glaucoma patients receiving long-term eye drop therapy in compared with the combination of anti-glaucoma eye drops.

Y. Ito. School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.

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Classification:

11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)

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