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Abstract #46717 Published in IGR 13-3
Immediate changes in intraocular pressure after an intravitreal injection of 2.5 mg of bevacizumab
Wu L; Evans TArchivos de la Sociedad Española de Oftalmologia 2010; 85: 364-369
Purpose: To report the immediate changes of intraocular (IOP) pressure after an intravitreal injection of 2.5 mg (0.1 ml) of bevacizumab. Methods: Prospective, non-controlled, interventional case series of 45 patients undergoing intravitreal injection of 2.5 mg (0.1 mL) of bevacizumab for a variety of retinal disorders. IOP was measured with a Goldmann tonometer at baseline, immediately after, 30 minutes and one day after injection in all of the cases. The main outcome measured was the IOP immediately after injection. Results: At baseline the mean IOP was 16.6 (plus or minus) 2.8 mm Hg (range, 10-24 mm Hg; median, 16 mm Hg; 25(th) percentile, 14 mm Hg and 75(th) percentile, 18 mm Hg). IOP rose to 53.9 (plus or minus) 18.2 mm Hg (range, 16-78 mm Hg, median, 54 mm Hg; 25(th) percentile, 40 mm Hg and 75(th) percentile, 70 mm Hg; p < 0.001) immediately after the injection. After 30 minutes, the IOP normalized but was still higher than baseline with a mean of 19.8 (plus or minus) 5.2 mm Hg (range, 10-36 mm Hg; median,18 mm Hg; 25(th) percentile,16 mm Hg and 75(th) percentile, 24 mm Hg; P < .01). At 24 hours the IOP was 15.7 (plus or minus) 3.1 mm Hg (range,10-24 mm Hg; median, 16 mm Hg; 25(th) percentile,14 mm Hg and 75(th) percentile,18 mm Hg; p > 0.05). Conclusions: An intravitreal injection of 2.5 mg (0.1 ml) of bevacizumab causes a transient elevation of IOP that tends to return to normal 30 minutes later.
L. Wu. Instituto de Cirugia Ocular, San Jose, Costa Rica.
Classification:
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
9.4.11.5 Glaucomas associated with vitreoretinal surgery (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.11 Glaucomas following intraocular surgery)
