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Abstract #46760 Published in IGR 13-3
Morphologic assessment for glaucoma in the multicenter uveitis steroid treatment (MUST) trial
Gangaputra SS; Altaweel MM; Peng Q; Friedman DS; Rao PK; Foster CS; Kim RY; Reed SB; Srivastava SK; Wong IGOcular Immunology and Inflammation 2011; 19: 267-274
Purpose: To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial. Methods: Clinical estimation of CDR was performed by ophthalmologists via dilated biomicroscopy. Photographic evaluation was performed at an independent RC by masked, certified evaluators. Quality control was performed by repeat grading of 77 randomly selected images. Results: Among 479 eyes with uveitis, 353 eyes had clinical and photographic grades for CDR. Agreement between clinical and RC grading was fair, with exact agreement of 29%. Agreement within 0.1 and 0.2 CDR was 70 and 93%, respectively (weighted (kappa)=.34). Intergrader reproducibility at the RC was better (weighted (kappa)=.59, ICC 0.74). Conclusion: Morphologic assessment of cup to disc ratio is an important outcome and safety measure for determining glaucomatous damage in clinical trials. Masked RC measurements are more likely to be accurate than biomicroscopic grading in identifying meaningful anatomical change associated with glaucoma.
M.M. Altaweel. Fundus Photograph Reading Center, Dept. of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 8010 Excelsior Drive, Madison, WI 53717, United States.
Classification:
9.4.6 Glaucomas associated with inflammation, uveitis (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
