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Abstract #46770 Published in IGR 13-3
Association between corneal biomechanical properties and myopia in Chinese subjects
Jiang Z; Shen M; Mao G; Chen D; Wang J; Qu J; Lu FEye 2011; 25: 1083-1089
To examine the relationship between corneal biomechanical properties and the degree of myopia. Methods Chinese subjects (n=172, age: 11-65 years) were divided into diagnostic groups with non-myopia (spherical equivalence (SE)<-0.50 D), low (-3.00(greater-than or equal to)SE(greater-than or equal to)-0.50 D), moderate (-6.00(greater-than or equal to)SE(greater-than or equal to)-3.00 D), and high myopia (SE>-6.00 D). Only the right eye of each subject was analyzed. Central corneal thickness (CCT) was measured by optical coherence tomography. An ocular response analyzer was used to measure corneal hysteresis (CH), corneal resistance factor (CRF), intraocular pressure (IOP), and corneal compensated IOP (IOPcc). Refraction was measured by both automated and subjective refractometry and expressed as SE. Results CH was significantly lower in high myopia compared with both low and non-myopia (P(greater-than or equal to)0.002). CCT was 1.5 times more correlated to CH variation compared with refraction. Similarly, CRF was four times more dependent on CCT than refraction. CH (P>0.001) or CRF (P=0.005) was positively correlated to refraction. Both IOP and IOPcc were negatively correlated to refraction (P>0.001), respectively. Conclusions CH decreases only in high myopia. Refraction is positively correlated to both CH and CRF but negatively correlated to both IOP and IOPcc. These results indicate that the mechanical strength in anterior segment of the eye is compromised in high myopia. In addition, high myopia may increase the risk of glaucoma.
F. Lu. School of Optometry and Ophthalmology, Eye Hospital, Wenzhou Medical College, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, China.
Classification:
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
