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Abstract #46778 Published in IGR 13-3
Formulation and evaluation of dorzolamide hydrochloride polymeric film
Tandale YN; Wagh VDInternational Journal of PharmTech Research 2011; 3: 1817-1824
The dorzolamide hydrochloride is a potential drug that can reduce intraocular pressure. The aim of the present study was to formulate and evaluate ophthalmic film of dorzolamide hydrochloride. The matrix drug delivery system of dorzolamide hydrochloride were prepared by evaporation (moulding) technique. Twelve formulations were developed, which differed in the combinations of polymers HPMC, Eudragit RS 100 and Eudragit RL 100 and at their different concentrations. PEG 400 was incorporated as a plasticizer. The prepared inserts were evaluated for various parameters like drug interaction studies, physicochemical characteristics, in vitro release studies, transcorneal permeation study by using excised goat cornea. There was no interaction between drug and polymer as revealed by UV absorption spectra and IR spectra of pure drug and drug and polymers mixture. The values of physicochemical evaluation were considered satisfactory and reveals good film properties. The surface pH of the prepared insert were between 6 to 7 which shows that the prepared insert would not alter the pH of tear fluid and does not have irritation potential as pH is within the accepted ocular range. The formulation DH 10 (1.25%w/v Eudragit RS 100, 2.50% w/v Eudragit RL 100, 40mg drug) sutained the drug release upto 24 hrs.
Y. N. Tandale. Department of Pharmaceutics, K.B.H.S.S.T'S Institute of Pharmacy, Bhaygaon Road, Malegaon. Dist Nasik- 423105, Maharashtra, India.
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)