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Abstract #46781 Published in IGR 13-3
Thermosensitive in situ gel of Timolol Maleate for the treatment of open angle glaucoma
Yeole PG; Iyer DResearch Journal of Pharmaceutical, Biological and Chemical Sciences 2011; 2: 1048-1064
The objective of this study was to develop a novel chitosan- chondroitin 6 sulphate insitu gel system for sustained drug delivery of timolol maleate. To increase the low bioavailability and short ocular residence time of timolol maleate eye drops, aqueous solutions of drug in combinations with the polymers were prepared to identify suitable compositions with regard to gel forming properties and drug release behavior. Mixtures of solutions of Pluronic (15-25% w/w), chitosan (0.05-0.3% w/w) of low molecular weight (Mw), chondroitin 6 sulphate (0.05-0.3% w/w) were prepared. Timolol maleate release was determined using a membraneless dissolution model in artificial tear solution up to 8 hours and the samples were analyzed spectrophotometrically at 294 nm. The rheological behavior of solutions in response to dilution or temperature changes and also the phase change temperature (PCT) were determined using a brookfield viscometer. The formulation consisting of 15% Pluronic, 0.05% chondroiitn 6 sulphate and 0.05% low Mw chitosan, depicted highest release efficiency coupled with an acceptable mean release time and is suggested as a suitable ophthalmic preparation for sustained release of timolol maleate. This in situ gel was liquid in non-physiologic conditions (pH 4 and 25(degrees)C) and transferred to the gel form upon exposure to physiologic conditions (pH 7.4 and 37(degrees)C). The PCT of this in situ gel did not change upon dilution.
P.G. Yeole. Dept of Pharmaceutics, Institute of Pharmaceutical and Educational Research (Iper), Borgaon (Meghe), Wardha - 442 001, Maharashtra, India.
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
