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Abstract #46803 Published in IGR 13-3
Assessment of Corneal Biomechanical Properties in Normal Tension Glaucoma and Comparison With Open-angle Glaucoma, Ocular Hypertension, and Normal Eyes
Grise-Dulac A; Saad A; Abitbol O; Febbraro J-L; Azan E; Moulin-Tyrode C; Gatinel DJournal of Glaucoma 2011;
PURPOSE: To assess the biomechanical properties of corneas in patients with normal tension glaucoma (NTG) and to compare them with those of patients with primary open-angle glaucoma (POAG), ocular hypertension (OHT), and normal controls (N). METHODS: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann intraocular pressure (IOPg), and corneal compensated IOP (IOPcc) were obtained using an ocular response analyzer for 28 eyes in 14 patients with NTG, 75 eyes in 38 patients with chronic POAG, 53 eyes of 27 patients with OHT, and 44 eyes of 22 N controls. IOP using Goldmann applanation tonometry (IOPGA) and ultrasonic central corneal thickness (CCT) were also measured for each eye. Analysis of variance test was used for statistical analysis. RESULTS: CH was significantly lower in the NTG group (9.88(plus or minus)2.02 mm Hg) compared with the N group (11.05(plus or minus)1.53 mm Hg; P<0.01). CRF was significantly lower in the NTG group (9.5(plus or minus)1.89 mm Hg) compared with the POAG group (11.15(plus or minus)2.35 mm Hg; P<0.01) and to the N group (11.00(plus or minus)1.75 mm Hg; P<0.01). CCT was not considered significantly different between the 4 groups. However, IOPcc was found to be significantly lower in NTG group compared with the POAG group and OHT group (P<0.001). CONCLUSION: NTG was associated with significantly lower CRF than chronic POAG and N patients. CH and CRF could be a useful tool in early diagnosis of NTG.
A. Grise-Dulac.
Classification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
9.2.1 Ocular hypertension (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.2.3 Open angle glaucoma with elevated IOP (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
