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Abstract #46817 Published in IGR 13-3
Angle closure in caucasians-a pilot, general ophthalmology clinic-based study
Barkana Y; Dekel I; Goldich Y; Morad Y; Avni I; Zadok DJournal of Glaucoma 2011;
PURPOSE: To assess the rate of clinically significant angle closure in a predominantly Caucasian, clinic-based population, and consequently find out whether gonioscopy should be included in the routine ophthalmic examination. METHODS: Patients aged (greater-than or equal to)40 years with hyperopia (greater-than or equal to)1 D were consecutively recruited in a community general ophthalmology clinic. Detailed darkroom gonioscopy was done, and primary angle closure was diagnosed if there was iridotrabecular apposition >180 degrees not secondary to an identifiable ocular disorder. Biometric parameters were measured and compared between the eyes with and without angle closure. RESULTS: Eighty-four eyes from 84 patients (aged 61.3(plus or minus)8.9 y) were enrolled. There were 52 female (62%) and 32 male. Fourteen patients (16.7%) were diagnosed with angle closure. A statistically significant difference was observed between the eyes with and without angle closure in mean axial length (22.07(plus or minus)0.72 vs. 22.61(plus or minus)0.97, P=0.028), anterior chamber depth (ACD) (2.45(plus or minus)0.33 vs. 2.89(plus or minus)0.32, P<0.001), and lens thickness (4.97(plus or minus)0.3 vs. 4.62(plus or minus)0.4, P=0.002). Degree of hyperopia was marginally significant (3.13(plus or minus)2.3 vs. 2.45(plus or minus)1.5, P=0.09). In a logistic regression model, only ACD remained statistically significantly different (P=0.016). We tested the ability of ACD to distinguish eyes with angle closure. The area under the receiver operating characteristic curve was 0.824; using a cutoff ACD value of 2.65 mm, sensitivity was 0.786 with a specificity of 0.812. CONCLUSIONS: Clinically significant angle closure, mandating close follow-up or preventive procedures, may be more common in Caucasians than currently thought. We recommend that gonioscopy should be included in the routine ophthalmic examination of all adults with hyperopia.
Y. Barkana.
Classification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
