advertisement
Abstract #46843 Published in IGR 13-3
Comparison of intraocular pressure-lowering effect of every night versus every other night dosing of bimatoprost 0.03%
Shazly TA; Latina MAJournal of Ocular Pharmacology and Therapeutics 2011; 27: 369-371
See also comment(s) by Louis Cantor •
Purpose: To compare intraocular pressure (IOP) reduction profiles of bimatoprost 0.03% administered every other night (QOD-HS) compared with every night (QHS) in patients with primary open angle glaucoma and pseudoexfoliation glaucoma. Methods: A retrospective chart review of 68 eyes of 45 consecutive patients who were switched from QHS to QOD-HS bimatoprost due to intolerable conjunctival hyperemia between May 2005 and May 2008. IOP in the morning (AM) and afternoon (PM) of the next day after administration (day 1) and the day after (day 2) on QOD-HS regimen was compared with IOP in the AM and PM when they were on QHS regimen, 4-6 weeks after switching to QOD-HS. Results: Mean IOPs on QHS bimatoprost were 15.9(plus or minus)3.4 mm Hg in the AM and 15.5(plus or minus)2.7 mm Hg in the PM, whereas mean IOPs on QOD-HS were 14(plus or minus)2 mm Hg (AM) and 14.2(plus or minus)2.5 mm Hg (PM) on day 1, and 14.7(plus or minus)2.6 mm Hg (AM) and 14.4(plus or minus)2.4 mm Hg (PM) on day 2 after administration. Differences between IOP fluctuation on QHS and QOD-HS days 1 and 2, respectively, were not significant (P=0.87 and 0.94). Conclusion: Every other night dosing of bimatoprost was effective in controlling IOP in this select group of patients with primary open angle glaucoma and pseudoexfoliation glaucoma who had troublesome side effects on bimatoprost 0.03% QHS regimen, and may be considered as an alternative to every day treatment.
T.A. Shazly. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary/Harvard Medical School, 20 Pondmeadow Dr, Boston, MA 01867, United States.
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
9.2.3 Open angle glaucoma with elevated IOP (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
