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Miscellaneous (32)

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Abstract #46847 Published in IGR 13-3

Comparison of selective laser trabeculoplasty success in patients treated with either prostaglandin or timolol/dorzolamide fixed combination

Kara N; Altan C; Satana B; Altinkaynak H; Bozkurt E; Demirok A; Yilmaz OF
Journal of Ocular Pharmacology and Therapeutics 2011; 27: 339-342

See also comment(s) by Jay Katz •

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Purpose: The purpose of this study was to compare the efficacy of selective laser trabeculoplasty (SLT) in eyes of patients with open-angle glaucoma receiving either a prostaglandin (PG) analog or a timolol/dorzolamide fixed combination (TDFC). Methods: In this retrospective study, we analyzed 48 eyes of 35 patients who underwent SLT for open-angle glaucoma receiving either a PG analog (n=20) or a TDFC (n=28). Mean decrease in intraocular pressure (IOP) and success rates were compared between patients treated with PG and those treated with TDFC. Success was defined as an IOP reduction of at least 20% at postoperative 1 year. Results: The mean decrease in IOP in eyes treated with PG and in eyes treated with TDFC were 4.1(plus or minus)3.1 and 4.6(plus or minus)3.5 at 1 week (P=0.579), 5.3(plus or minus)3.4 and 5.7(plus or minus)2.0 at 1 month (P=0.485), 5.2(plus or minus)3.1 and 5.5(plus or minus)2.5 at 3 months (P=0.271), 5.0(plus or minus)3.1 and 6.1(plus or minus)2.5 and at 6 months (P=0.044), and 4.7(plus or minus)3.1 and 6.5(plus or minus)2.9 at 1 year (P=0.017), respectively. The success rate at postoperative 1 year was 50.0% (standard deviation(plus or minus)16) in eyes receiving PG and 78.6% (standard deviation:(plus or minus)11) in eyes receiving TDFC (P=0.041). Conclusion: This study shows that the SLT seems to be more effective in TDFC users than PG analog users.

N. Kara. Beyoglu Eye Research and Education Hospital, Kartaltepe Mh. Akin Sk. Akin Apt. No:8/14, Bakirkoy, Istanbul 34330, Turkey.

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Classification:

12.4 Laser trabeculoplasty and other laser treatment of the angle (Part of: 12 Surgical treatment)
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.13.2 Betablocker and carbon anhydrase inhibitor (Part of: 11 Medical treatment > 11.13 Combination therapy)

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