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Abstract #46872 Published in IGR 13-3
Quality of life in ocular hypertension and primary open angle glaucoma
Wolfram C; Lorenz K; Shlaen R; Verboven Y; Pfeiffer NValue in Health 2010; 13: A402
OBJECTIVES: To estimate the impact of ocular hypertension (OHT)/primary openangle glaucoma (POAG) on health status and quality-of-life. METHODS: Classification of disease state followed European Glaucoma Society guidelines. Health status was based upon the Health Utility Index Mark 3 (HUI3) The National Eye Institute 25-Item Visual Function Questionnaire (NEI-VFQ-25) was self-administered. Utility scores were compared to a normal population matched by age and gender. Differences in health impact and quality-of-life between the different disease states were assessed. RESULTS: 154 patients were enrolled (27 OHT, 43 early, 35 moderate, 49 advanced POAG) from 15 centers in Germany, 137 were diagnosed 35 years ago. Average age was 67 (plus or minus) 11 and 57% were female. 23% of patients had cardiovascular co-morbidity, 45% history of cataract, 45% hypertension, 18% diabetes, and 10% hypotension. Differences in baseline characteristics were seen for age (60, 63, 69, 72 years), history of cataract (24%, 25%, 54%, 62%), employment status (43%, 24%), and hypotension (14%, 0%, 14%, 15%). The HUI3 score for OHT, early, moderate and advanced POAG was 0.87 (plus or minus) 0.09, 0.85 (plus or minus) 0.15, 0.75 (plus or minus) 0.23 and 0.58 (plus or minus) 0.32, respectively. There was no difference in the health utility score for patients with OHT, early POAG and the normal population. Patients with moderate and advanced POAG were lower by 0.06 (plus or minus) 0.24 and 0.19 (plus or minus) 0.28, significantly different from OHT and early POAG (P < 0.01). The NEI-VFQ-25 for OHT and early POAG gave ocular symptoms and mental health the lowest scores. For moderate POAG the lowest scores were for driving, ocular symptoms, mental health, role limitation and peripheral vision. For advanced POAG, all domains, except color vision, were affected. CONCLUSIONS: Disease progression in glaucoma affects not only vision, but also quality-of-life. Whereas OHT and early POAG have little effect on quality-of-life, moderate and advanced POAG do. These findings can improve doctor-patient relationships, addressing quality-of-life issues for different glaucoma disease states.
C. Wolfram. Universitatsmedizin Mainz, Mainz, Germany.
Classification:
1.4 Quality of life (Part of: 1 General aspects)
9.2.1 Ocular hypertension (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.2.3 Open angle glaucoma with elevated IOP (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
