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Abstract #46893 Published in IGR 13-3
Retinal nerve fiber layer measurement and diagnostic capability of spectral-domain versus time-domain optical coherence tomography
Kaushik S; Pandav SS; Ichhpujani P; Gupta A; Gupta PEuropean Journal of Ophthalmology 2011; 21: 566-572
To compare retinal nerve fiber layer (RNFL) thickness and diagnostic capability of spectraldomain (Cirrus(trademark)) versus time-domain (Stratus((registered trademark))) optical coherence tomography (OCT). Methods. A total of 123 eyes of 123 subjects including 68 normal, 32 glaucoma suspect, and 23 patients with glaucoma were prospectively recruited for the study. All subjects were scanned by StratusR and Cirrus(trademark) OCT in the same session. Average and quadrant peripapillary RNFL measurements by both machines were correlated using Spearman correlation coefficient, and agreement between testing methods was analyzed by Bland-Altman plots. The area under receiver operating characteristic curves (AUC) for glaucoma diagnosis was calculated. Results. Average RNFL thickness were significantly thinner on the Cirrus(trademark) compared to the Stratus((registered trademark)) OCT in normal subjects and glaucoma suspects (p<0.001), but thicker on the Cirrus(trademark) OCT in glaucoma patients, though the difference was not statistically significant (p=0.53). There was good correlation between the measurements in all 3 groups. In normal controls, the average, superior, nasal, inferior, and temporal correlations were r=0.668, 0.601, 0.508, 0.620, and 0.660, p<0.001, respectively. In glaucomatous eyes, the corresponding values were r=0.560, p=0.005; r=0.423, p=0.04; r=0.117, p=0.596; r=0.742, p<0.001; r=0.669, p<0.001, respectively. The 95% limits of agreement of average RNFL thickness were -30.2 to 13.8 (mu)m. Area under receiver operating characteristic curves for diagnosing glaucoma were comparable (superior RNFL thickness by Cirrus(trademark) 0.925; average RNFL thickness by Stratus((registered trademark)) 0.987). Highest correlated AUCs were for inferior and temporal quadrants. Conclusions. Retinal nerve fiber layer measurements on the Cirrus(trademark) and Stratus((registered trademark)) OCT correlate well but do not have clinically acceptable agreement between their measurements. The instruments may not be used interchangeably.
S. S. Pandav. Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
