advertisement
Abstract #46919 Published in IGR 13-3
Changes in corneal parameters at confocal microscopy in treated glaucoma patients
Ranno S; Fogagnolo P; Rossetti L; Orzalesi N; Nucci PClinical Ophthalmology 2011; 5: 1037-1042
Background: The purpose of this study was to evaluate corneal parameters in treated glaucoma patients, nontreated glaucoma patients, and normal subjects using confocal microscopy. Methods: Forty patients with primary open-angle glaucoma and 22 untreated controls underwent confocal microscopy of the cornea using the Heidelberg retinal tomograph cornea module. The glaucoma group was divided into two subgroups, ie, patients on medical treatment for at least two years before inclusion (with beta-blockers or prostaglandin analogs) and nontreated glaucoma patients. The following corneal parameters were evaluated: endothelial cell density and number, reflectivity, and tortuosity of sub-basal nerves. For reflectivity and tortuosity, a dedicated grading scale ranging from 0 to 4 was used. Differences between treatments were also evaluated in the treated glaucoma group. Results: Number of fibers and reflectivity of the sub-basal plexus were significantly lower in glaucoma patients as compared with controls (2.5 (plus or minus) 0.7 versus 2.9 (plus or minus) 0.9, P = 0.006, and 2.3 (plus or minus) 0.8 versus 2.7 (plus or minus) 0.9, P = 0.04, respectively), whereas tortuosity was significantly higher (2.6 (plus or minus) 1 versus 2.0 (plus or minus) 0.8, P = 0.007). Endothelial cell density (measured as cells per mm2) was lower in the glaucoma group comparing treated patients with nontreated patients (2826 (plus or minus) 285 versus 3124 (plus or minus) 272, P = 0.0003). Comparing treated patients with nontreated patients, relevant differences were found in number (2.3 (plus or minus) 0.7 versus 2.8 (plus or minus) 0.8, P = 0.004), tortuosity (2.8 (plus or minus) 1 versus 2.2 (plus or minus) 0.8, P = 0.004), and reflectivity (2.2 (plus or minus) 0.8 versus 2.6 (plus or minus) 0.8, P = 0.04). No differences in corneal parameters were found between beta-blockers and prostaglandin analogs. Conclusion: This study shows that differences in corneal parameters between glaucoma patients and controls may be due to the medical treatments used for glaucoma. These data should be taken into consideration in long-standing medical glaucoma treatment and in potential candidates for surgery.
S. Ranno. Via San Vittore 12, Milan, Italy.
Classification:
6.9.2.1 Anterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)