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Abstract #46966 Published in IGR 13-3
Motion-onset visual evoked potentials provide unique diagnostic info - II. Clinical studies
Kubova Z; Kuba M; Kremlacek J; Szanyi J; Langrova J; Vit FClinical Neurophysiology 2011; 122: 152-153
Introduction: Motion-onset visual evoked potentials (M-VEPs) represent an objective method for testing the function of the magnocellular and/or dorsal stream of the visual pathway (Kubova et al. Vis. Res. 1995; 35:197-205). Objectives: For more than twenty years, our laboratory has been engaged in improvement of the M-VEPs methods and also in testing the usability of these VEPs in clinical practice. Here we present results of our experience in this respect. Methods: The contribution of the M-VEPs examination (indicating mainly magnocellular system and dorsal stream activity) compared to the standard pattern-reversal (P-VEPs) examination (predominant parvocellular system and striate cortical activity) was tested in the following diagnoses: Multiple Sclerosis, Optic Neuritis, Neu-roborreliosis, Glaucoma, Amblyopia, Dyslexia, Congenital Nyctalopia, Perinatal CNS impairment and Alzheimer's disease (see publications at http://www.lfhk.cuni.cz/elf). Results: The extended VEP examination increases sensitivity (in cases with pathological M-VEP and normal P-VEPs latencies) for about 28% (data from about 3000 patients). The M-VEPs are well detectable in about 50(degrees) of the visual field, so they can be used for objective detection of its reduction in glaucoma. In amblyopes with severe VA decrease (with absent P-VEPs), M-VEPs can help to recognize additional pathology of the amblyopic eye. A distinct delay of the M-VEPs in some dyslexics can be interpreted as a sign of supposed magnocellular deficit. In premature born children the M-VEPs are more sensitive for detection of the visual pathway pathology and evaluation of its possible recovery. In Alzheimer's disease patients M-VEPs confirm a defect of motion processing. Conclusion: On the basis of the presented pilot studies, we suggest that the M-VEPs should be included as an obligatory part of the electrophysiological examination in visual and CNS disorders.
Z. Kubova. Department of Pathophysiology, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)