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Abstract #47013 Published in IGR 13-3
Energy as a cause of nerve damage in Glaucoma: A theory on some mechanisms
Hetland JGTechniques in Ophthalmology 2011; 9: 50-53
Purpose: The aim of the study was to analyze the effect of mechanical energy on retinal nerve fibers and axons attached to lamina cribrosa (LC). METHODS:: The author developed and used a dynamic analysis approach for assessment of possible association between work generated by the mechanical energy in the eye and its possible effects on the neural tissue. RESULTS:: Intraocular pressure waves work continuously on the retinal nerve fibers and axons. During systole, the nerve fibers become more tightly attached to the retinal bed, whereas the LC is displaced posteriorly. This combination causes traction and stretching of the nerve fibers over the scleral rim acting as a fulcrum and could cause physical damage of axons and disruption of axonal transport. CONCLUSIONS:: Mechanical energy from the blood pressure and aqueous humor flow are stress factors for the retinal nerve fibers and axons attached to the LC. In the long run, the combined mechanisms of compression, displacement of LC, traction, and stretching of the nerve fibers and axons could lead to the destruction of neural tissue irrespective of the level of intraocular pressure.
J.G. Hetland. Nordsetergrenda 15 B, 1161 Oslo, Norway.
Classification:
1.3 Pathogenesis (Part of: 1 General aspects)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)
