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Abstract #47014 Published in IGR 13-3
Adjunctive bevacizumab in patients undergoing Ahmed valve implantation: A pilot study
Rojo-Arnao M; Albis-Donado OD; Lliteras-Cardin M; Kahook MY; Gil-Carrasco FOphthalmic Surgery Lasers and Imaging 2011; 42: 132-137
See also comment(s) by Kouros Nouri-Mahdavi •
BACKGROUND AND OBJECTIVE: To report on preliminary findings of adjunctive subconjunctival bevacizumab (SCB) injections in patients undergoing Ahmed valve implantation (AVI) (New World Medical, Rancho Cucamonga, CA). PATIENTS AND METHODS: The study was approved by the institution's ethics committee. Patients were prospectively recruited during a 1-month period and randomized to receive AVI with postoperative SCB (days 1 and 7, n = 7) or AVI without SCB (n = 6). RESULTS: Baseline intraocular pressure (IOP) in the treatment (AVI+SCB) group was 19.4 (plus or minus) 8.6 mm Hg, whereas baseline IOP in the control (AVI) group was 32.1 (plus or minus) 17.7 mm Hg (P = .119). Final IOP was 13.8 mm Hg (n = 7) for the treatment group and 12.7 mm Hg for the control group (n = 5, P = .790). One eye in the control group required further glaucoma intervention at day 45 and was considered a failure. The pre-massage postoperative IOP was significantly lower for the treatment group only at day 45 (16.1 vs 26.0 mm Hg, P = .012). Mean post-massage IOP was significantly lower in the treatment group at day 15 (11.28 vs 17.16 mm Hg, P = .004), day 30 (11.28 vs 20.83 mm Hg, P = .015), and day 45 (12.16 vs 21.33 mm Hg, P = .001), and similar at month 3. Mean change in bleb area was 11.4 mm2 in the treatment group and -0.4 mm2 in the control group (P = .036 and P = .361, respectively, Student's paired samples t test). CONCLUSION: Bevacizumab was associated with a less aggressive hypertensive period as measured by post-massage IOP measurements, postoperative glaucoma medications, and cross-sectional bleb area by ultrasound. Further prospective studies are needed to better understand the utility of SCB at the time of AVI surgery.
O. D. Albis-Donado. Asociacion para Evitar la Ceguera en Mexico, Departamento de Glaucoma, Vicente Garcia Torres #46, Col. San Lucas, Coyoacan, Mexico DF, CP 04030, Mexico.
Classification:
12.8.2 With tube implant or other drainage devices (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)