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Abstract #47075 Published in IGR 13-3
The relationship between central corneal thickness and optic disc size in patients with primary open-angle glaucoma in a hospital-based population
Terai N; Spoerl E; Pillunat LE; Kuhlisch E; Schmidt E; Boehm AGActa Ophthalmologica 2011; 89: 556-559
Purpose: To investigate the relationship between central corneal thickness (CCT) and optic disc size in patients with primary open-angle glaucoma (POAG) in a hospital-based population. Methods: Data for the right eyes of 1435 White patients with POAG were included in a retrospective hospital-based study. All eyes underwent optic nerve head imaging using Heidelberg Retina Tomograph II (HRT II; Heidelberg Engineering, Heidelberg, Germany) and CCT measurement by ultrasound corneal pachymetry. Eyes with prior intraocular or corneal surgery were excluded. Low-quality HRT II images were also excluded. The impact of age, gender, CCT, intraocular pressure, cylindrical and spherical refractive error as independent factors on optic disc size was investigated in a multiple linear regression analysis. Results: The data for 1104 right eyes qualified for participation in the study. The median age of these patients was 65 years. The median CCT was 547 (mu)m (25th-75th percentile 522-575 (mu)m). The median optic disc size was 2.21 mm(2) (25th-75th percentile 1.89-2.60 mm (2)). Multiple linear regression analysis revealed that age (p = 0.001), CCT (p = 0.001) and spherical equivalent (p = 0.049) were correlated to disc size according to the following formula: disc area = -0.004 null age - 0.001 null CCT - 0.014 null spherical equivalent +3.290. R(2) of the whole model was 0.021. Univariate regression analysis between age and disc area provided R(2) = 0.008 with p = 0.002. Univariate regression analysis between disc area and CCT provided R(2) = 0.005 with p = 0.02. Conclusion: In this retrospective hospital-based study we could not detect a clinically relevant correlation between optic disc size and CCT. The correlation between CCT and disc size and between age and disc size were statistically significant, but the R(2) values were very low. The results of the study are biased because of its hospital-based design, so the results of the study need to be confirmed in a large population-based study.
N. Terai. Department of Ophthalmology, Carl Gustav Carus University Hospital, Fetscherstr 74, 01307 Dresden, Germany.
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
