advertisement
Abstract #47097 Published in IGR 13-3
The effect of prostaglandin analogues on central corneal thickness of patients with chronic open-angle glaucoma: A 2-year study on 129 eyes
Bafa M; Georgopoulos G; Mihas C; Stavrakas P; Papaconstantinou D; Vergados IActa Ophthalmologica 2011; 89: 448-451
Purpose: To evaluate the effect of prostaglandin analogues on the central corneal thickness (CCT) of patients with chronic open-angle glaucoma (COAG). Methods: One hundred and twenty-nine eyes were included in this study. Of these, 108 were treated with prostaglandin analogues (latanoprost, travoprost and bimatoprost), while 21 eyes treated with (beta)-blockers were used as controls. CCT was measured before treatment and at 3-month intervals. Results: A slight but significant increase in CCT was recorded in the bimatoprost and latanoprost groups. Treatment with bimatoprost produced a constant increase (1.85-8.83 (mu)m) in CCT at all time-points of the study. The CCT rise found in the latanoprost group was significant for the first year. Treatment with travoprost did not affect CCT. Conclusion: The possibility of corneal thickening under prolonged, local prostaglandin treatment should be investigated further. However, in clinical practice, CCT changes may sometimes influence intraocular pressure measurements significantly.
M. Bafa. 7 Makedonias St., 14121-Athens, Greece.
Classification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
11.4 Prostaglandins (Part of: 11 Medical treatment)
