advertisement
Abstract #47697 Published in IGR 13-4
Optical coherence tomography shows progressive local nerve fiber loss after disc hemorrhages in glaucoma patients
Kernstock C; Dietzsch J; Januschowski K; Schiefer U; Fischer MDGraefe's Archive for Clinical and Experimental Ophthalmology 2011;
Background and aim: The aim of this work is to investigate whether optic disc hemorrhages (ODH) lead to significant loss of nerve fibers at the lesion site over time and whether such a loss is reflected by visual field defects corresponding to the affected nerve fiber bundle. Methods: In this retrospective study of ten sequential glaucoma patients (ten eyes) with ODH, we used high-resolution OCT circular scans (Spectralis HRA + OCT, Heidelberg Engineering, Heidelberg, Germany) to determine peripapillary retinal nerve fiber layer (RNFL) thickness at the time of ODH presentation and at follow-up visit between 3 and 6 months. Corresponding perimetric data were analyzed for global (mean defect, MD) and localized progression of visual field defects. Results: ODH were mostly located in the inferior quadrant as determined clinically and from fundus photographs. Iterative OCT imaging revealed a significant RNFL reduction in the affected quadrant relative to the respective quadrant in the fellow eye (RNFL change = -2.25 (plus or minus) 2.69 (mu)m vs. 0.75 (plus or minus) 2.78 (mu)m, p = 0.01) within 120 (plus or minus) 43 days. However, only three cases presented with new/progressive nerve fiber bundle defects corresponding to the lesion site within the given follow-up period. Conclusions: ODH lead to a significantly higher RNFL loss at the lesion site relative to the overall structural progression in glaucoma patients. However, this focal change is not generally reflected by respective nerve fiber bundle defects in the time frame investigated. (copyright) 2011 Springer-Verlag.
M.D. Fischer. University Eye Hospital, Centre for Ophthalmology, University of Tuebingen, Schleichstr 12-16, Tuebingen, 72076, Germany. Email: dominik.fischer@med.uni-tuebingen.de
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
9.4.10 Glaucomas associated with hemorrhage (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
