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Abstract #47732 Published in IGR 13-4
Influence of family history as a risk factor on primary angle closure and primary open angle glaucoma in a Chinese population
Kong X; Chen Y; Chen X; Sun XOphthalmic Epidemiology 2011; 18: 226-232
Purpose: To identify the likelihood of family history as a risk factor for the presence and severity of primary angle closure (PAC) and primary open angle glaucoma (POAG) in a Chinese population. Methods: All participants were asked to complete a questionnaire and undergo a comprehensive eye examination. Past history of hypertension, diabetes mellitus, hyperopia, high myopia, and family history of glaucoma were recorded. For those patients with a family history of glaucoma, the relationship between the patient and the affected relatives has been specified. Results: A total of 332 PAC patients, 228 POAG patients and 193 controls were included. Of the 332 PAC patients, 83 (25.00%) had glaucoma family history. Characteristic-adjusted odds ratio (OR) of family history for PAC was 4.82 [95% confidence interval (CI): 2.0811.19] and for severity of PAC was 1.61 (95% CI: 1.052.49). Among first-relatives only parents account for the family history rate of PAC [OR 8.76 (95% CI: 2.0038.32)]. Of the 228 POAG patients, 49 (21.49%) had a family history of glaucoma. Odds ratio for POAG was 8.38 (95% CI: 3.3321.07) and for severity of POAG was 1.81 (95% CI: 1.053.14). Unlike patients with PAC, only siblings and offspring account for the family history rate of POAG [OR 8.99 (95% CI: 2.3833.99) and OR 19.23 (95% CI: 1.53241.24) respectively]. Conclusion: Our study showed that a family history of glaucoma is associated with the presence and severity of PAC and POAG. This supports the finding that screening first-degree relatives will be an effective way to detect glaucoma in a population. (copyright) 2011 Informa Healthcare USA, Inc.
X. Sun. Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, 200031, Shanghai, China. Email: xhsun@shmu.edu.cn
Classification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.2.3 Open angle glaucoma with elevated IOP (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
