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Abstract #47783 Published in IGR 13-4
A short-term randomized clinical trial of daily versus alternate day use of travoprost 0.004% in the treatment of ocular hypertension
Khairy HA; Said-Ahmed KJournal of Glaucoma 2011;
See also comment(s) by Louis Cantor •
PURPOSE: To compare the daily versus the alternate day use of travoprost 0.004% in lowering the intraocular pressure (IOP) in patients with ocular hypertension. METHODS: Fourteen patients with ocular hypertension in both eyes have been randomly assigned to receive travoprost 0.004% once a day in 1 eye and once every other day in the other eye. The main outcome measure was change in the mean of the IOPs measured at 9:00 AM, and 4:00 PM between baseline (before treatment) and measurement of IOPs at 1, 2, 4, 8, and 12 weeks after treatment. RESULTS: After 3 months of treatment, daily use of travoprost 0.004% significantly reduced IOP (mean(plus or minus)standard error of mean) by 6.1(plus or minus)0.5 mmHg (P<0.001) and alternate day use by 5.9(plus or minus)0.3 mmHg (P< 0.001) adjusted from an overall baseline of 24.3(plus or minus)0.5 mm Hg. The difference in the IOP-lowering effect was not statistically significant (P<0.05). CONCLUSIONS: Alternate day use of travoprost 0.004% was as safe and effective as its daily use in lowering the IOP in patients with ocular hypertension.
H. A. Khairy.
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
