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Abstract #47785 Published in IGR 13-4
Association between plasma endothelin-1 and severity of different types of glaucoma
Chen H-Y; Chang Y-C; Chen W-C; Lane H-YJournal of Glaucoma 2011;
PURPOSE: Endothelin-1 (ET-1) has been suggested to play an important role in the pathogenesis of glaucoma. Herein, we studied whether increased levels of plasma ET-1 are associated with changes in the visual field and changes in optical coherence tomography (OCT)-measured retinal nerve fiber layer (RNFL) thickness in patients with different types of glaucoma. PATIENTS AND METHODS: Plasma concentration of ET-1 was determined in 31 patients with primary open-angle glaucoma, 18 patients with normal tension glaucoma, 16 patients with primary angle-closure glaucoma, and in 37 normal controls. In all participants, visual field testing was performed and OCT was used to measure RNFL thickness. The correlation between mean ET-1 level and changes in the visual field (mean deviation, dB) and changes in OCT-measured RNFL thickness in 1 randomly selected eye from each patient in each group was then evaluated. RESULTS: The ET-1 level was 3.27(plus or minus)1.25 pg/mL in the primary open-angle glaucoma group (-14.09(plus or minus)8.76 dB), 3.12(plus or minus)1.46 pg/mL in the normal tension glaucoma group (-8.87(plus or minus)6.15 dB), 2.58(plus or minus).22pg/mL in the primary angle-closure glaucoma group (-14.55(plus or minus)10.2 dB), and 1.53(plus or minus)1.49 pg/mL in the control group. Although mean ET-1 levels were significantly higher in all 3 of the glaucoma groups than in the control group, there was no significant difference in ET-1 level among the 3 glaucoma groups. In addition, no significant correlation was found between levels of plasma ET-1 and structural or functional changes in patients with different types of glaucoma. CONCLUSIONS: There was no correlation between plasma levels of ET-1 and severity of glaucoma. The role ET-1 plays in the pathogenesis of glaucoma remains to be determined.
H.-Y. Chen.
Classification:
3.7 Biochemistry (Part of: 3 Laboratory methods)
3.6 Cellular biology (Part of: 3 Laboratory methods)
1.3 Pathogenesis (Part of: 1 General aspects)
