advertisement
Abstract #47884 Published in IGR 13-4
Plasma homocysteine levels in patients with pseudoexfoliation
Ozturk AT; Arikan G; Kuralay F; Gunenc UTurkiye Klinikleri Journal of Medical Sciences 2011; 31: 1204-1210
Objective: To evaluate plasma homocysteine (Hcy) levels in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, primary open angle glaucoma and healthy control subjects. Material and Methods: Twenty patients with primary open angle glaucoma (POAG), twenty patients with pseudoexfoliation (PEX) glaucoma, twenty patients with PEX syndrome and twenty control subjects were enrolled. Mean plasma Hcy levels of four groups were determined using high-performance-liquid-chromatography and were compared. Then all participants were classified into two groups as subjects with or without PEX and were compared. Patients who had any history of a systemic disease known to be associated with high plasma Hcy levels and taking vitamin B supplements within the previous year were excluded. Results: Of the 80 patients, 43 were females (53.75%) and 37 were males (46.25%). Mean age was 69.11(plus or minus)8.53 years. Mean plasma Hcy levels were 19.02(plus or minus)10.66 (mu)mol/l, 19.13(plus or minus)17.76 (mu)mol/l, 10.58(plus or minus)3.50 (mu)mol/l and 9.92(plus or minus)2.59 (mu)mol/l in patients with PEX syndrome, PEX glaucoma, POAG and control subjects, respectively. Hcy levels in patients with PEX glaucoma were significantly higher when compared to POAG patients and the control group (p=0.025, p=0.004, respectively). Hcy levels in patients with PEX syndrome were also significantly higher when compared to POAG patients and the control group (p=0.001, p=0.000, respectively). Hcy levels in patients with POAG were not statistically different from the control group (p=0.365). When the patients were classified into two groups as subjects with or without PEX, mean plasma Hcy levels were found as 19.08(plus or minus)14.44 (mu)mol/l and 10.25(plus or minus)3.06 (mu)mol/l, respectively (p=0.000). Conclusion: Hcy levels were found to be significantly higher in PEX with or without glaucoma. (copyright) 2011 by Turkiye Klinikleri.
A. T. Ozturk. Dr. Behcet Uz Child's Diseases and Child Surgery Education and Research Hospital, Clinic of Ophthalmology, Izmir, Turkey. Email: ataylan6@yahoo.com
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
