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Abstract #47920 Published in IGR 13-4
ReGAE 7: Long-term outcomes of augmented trabeculectomy with mitomycin C in African Caribbean patients
Shah P; Agrawal P; Khaw PT; Shafi F; Sii FClinical and Experimental Ophthalmology 2011;
Background: To evaluate long-term outcomes and complication rates following trabeculectomy with mitomycin C in a case series of African Caribbean patients. Design: A prospective, observational and non-comparative case series. Participants: Forty-seven consecutive African Caribbean patients (47 eyes) with glaucoma. Methods: All patients underwent augmented trabeculectomy with mitomycin C for uncontrolled intraocular pressure (IOP). Survival analysis was performed with a minimum of 12months' follow up. Main Outcome Measures: Surgical success was based upon IOP reduction to (less-than or equal to)21mmHg, (less-than or equal to)18mmHg and (less-than or equal to)15mmHg without glaucoma medication (complete); or IOP reduction to (less-than or equal to)21mmHg, (less-than or equal to)18mmHg and (less-than or equal to)15mmHg with or without glaucoma medication (qualified). Results: The mean follow-up period was 48.6months. At 3years post-trabeculectomy 92.6% achieved a qualified success and 59.3% a complete success for an IOP (less-than or equal to)21mmHg. At final follow up the mean IOP reduced from 33.7mmHg to 13.1mmHg (P<0.0001). Survival rates were 96%, 90% and 86% at 12, 24 and 36months, respectively, with a mean survival time of 97.4months (95% confidence interval, 86.0-108.8) for an IOP (less-than or equal to)21mmHg. Early postoperative hypotony requiring surgical intervention occurred in four (8.5%) patients. There were no cases of blebitis, endophthalmitis, suprachoroidal haemorrhage, malignant glaucoma or hypotony maculopathy. Conclusions: Good long-term stable IOP can be achieved with low complication rates and high success rates amongst African Caribbean patients following trabeculectomy with mitomycin C. A proactive postoperative management regime is needed to ensure trabeculectomy survival in high-risk populations. (copyright) 2011 The Authors. Clinical and Experimental Ophthalmology (copyright) 2011 Royal Australian and New Zealand College of Ophthalmologists.
P. Shah. Professor Peter Shah, University Hospital Birmingham, Selly Oak Hospital, Raddlebarn Road, Birmingha, . Email: peter.shah@uhb.nhs.uk
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
