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Abstract #47935 Published in IGR 13-4
Topiramate induced acute secondary angle closure glaucoma and myopic shift: A case review
Pai SG; Pai A; Kamath G; Pai SR; Rathi NInternet Journal of Pharmacology 2011; 9: 2
Introduction: Acute myopia and secondary acute angle-closure glaucoma are serious adverse effects of topiramate use, both of which are reversible with immediate discontinuation of the drug. Topiramate is an oral sulfamate medication used primarily for epilepsy and migraine(1). Other uses of topiramate include use in management of peripheral neuropathies and radiculopathies, idiopathic intracranial hypertension, adjunctive therapy in alcohol dependence and nicotine cessation(2) Case presentation: A 40 year old man, on oral topiramate for alcohol dependence, presented with complaints of severe pain, redness and sudden loss of vision in both eyes since two days. Best corrected visual acuity was 20/20 in both eyes with minus three diopters sphere. A diagnosis of secondary angle closure glaucoma with myopic shift was made. Conclusion: Topiramate was discontinued immediately and anti glaucoma therapy initiated along with topical steroids. Unaided visual acuity returned to 20/20 in both eyes with normal anterior segment and intraocular pressure within one week of treatment.
A. Pai. Mahamaya Temple, Field Street, Mangalore-575001, Karnataka, India. Email: drashwinpai@gmail.com
Classification:
9.4.5.5 Other (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)