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Abstract #47954 Published in IGR 13-4
Systemic vascular dysregulation and retrobulbar hemodynamics in normal-tension glaucoma
Galassi F; Giambene B; Varriale RInvestigative ophthalmology & visual science 2011; 52: 4467-4471
To investigate the influence of systemic vascular dysregulation on retrobulbar hemodynamics in normal-tension glaucoma (NTG). Forty-four untreated patients with NTG and 40 healthy controls matched for age, sex, and intraocular pressure were included. Cold-induced nailfold capillaroscopic features, mean and diastolic ocular perfusion pressures (mOPP, dOPP), endothelin-1 (ET-1) and nitric oxide markers, as nitrates (NO(2)), plasma values were recorded. Peak-systolic velocity, end-diastolic velocity (EDV), and resistivity index (RI) were measured in the ophthalmic artery (OA), short posterior ciliary arteries, and the central retinal artery by color Doppler imaging. Differences between groups were determined by Student's t-test. Relationships among ET-1, NO(2), OPPs, and retrobulbar hemodynamics were assessed using correlation and multiple linear regression analyses. Altered capillaroscopy was more frequent (72.7% vs. 5.0%, P < 0.001), mOPP and dOPP values were lower (44.54 (plus or minus) 2.81 vs. 52.18 (plus or minus) 4.47 mm Hg; 57.89 (plus or minus) 4.30 vs. 68.28 (plus or minus) 6.91 mm Hg; P < 0.001), and ET-1 and NO(2) values were respectively higher and lower (1.62 (plus or minus) 0.22 vs. 1.12 (plus or minus) 0.20 pg/mL and 142.17 (plus or minus) 14.34 vs. 231.30 (plus or minus) 6.16 (mu)mol/mg prot; P < 0.001) in patients than the same values in controls. EDV was lower and RI higher in OA (5.87 (plus or minus) 1.17 vs. 11.41 (plus or minus) 2.30 cm/s; 0.76 (plus or minus) 0.03 vs. 0.64 (plus or minus) 0.03; P < 0.001) in subjects with NTG than in controls. In patients RI-OA was positively related to ET-1 (t = 2.704, P = 0.010) and negatively related to NO(2) (t = -4.477, P < 0.001). Impaired retrobulbar hemodynamics may proceed from a vascular endotheliopathy in patients with NTG.
F. Galassi. Clinica Oculistica, Universita di Firenze, Firenze, Italy.
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)